Vaccines for Invasive Fungal Infections Methods and Protocols

This detailed volume focuses on the development of mycosis vaccines via the most common etiological agents of mycoses, such as Aspergillus and Candida species, followed by Cryptococcus, dimorphic fungi, and members of Mucorac

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Markus Kalkum Margarita Semis Editors

Vaccines for Invasive Fungal Infections Methods and Protocols

Methods

in

Molecular Biology

Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK

For further volumes: http://www.springer.com/series/7651

Vaccines for Invasive Fungal Infections Methods and Protocols

Edited by

Markus Kalkum and Margarita Semis Department of Molecular Immunology, Beckman Research Institute of City of Hope, Duarte, CA, USA

Editors Markus Kalkum Department of Molecular Immunology Beckman Research Institute of City of Hope Duarte, CA, USA

Margarita Semis Department of Molecular Immunology Beckman Research Institute of City of Hope Duarte, CA, USA

ISSN 1064-3745     ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7103-9    ISBN 978-1-4939-7104-6 (eBook) DOI 10.1007/978-1-4939-7104-6 Library of Congress Control Number: 2017943158 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover illustration: Electron micrograph of an Aspergillus fumigatus conidiophore (spore head). Diameters of mature spores are approximately 1.4 µm. The leftmost image shows phagocytes (purple) attacking fungal hyphae (bluish-grey band) of A. fumigatus. Courtesy of Dr. Marcia Miller, Electron Microscopy Facility, Diana Diaz-Arevalo & Markus Kalkum, Department of Molecular Immunology, Beckman Research Institute of the City of Hope. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.

Preface Invasive mycoses are severe fungal infections that threaten the lives of thousands of patients with immunosuppressive conditions. As such, the disease targets t