Immune globulin
- PDF / 123,029 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 71 Downloads / 176 Views
1
S
Anaphylaxis, with subsequent desensitisation: case report A 58-year-old woman with Bruton’s agammaglobulinaemia-like disease developed anaphylaxis while receiving IV immune globulin [Gammagard Liquid]. She subsequently underwent successful desensitisation with SC immune globulin [Vivaglobin]. The woman started receiving an IV infusion of 10% immune globulin 30mg (500 mg/kg) at 30 mL/h. Nine minutes later, she experienced an anaphylactic reaction, with nausea, flushing, dyspnoea, abdominal cramps and the urge to defecate. A detailed history revealed previous reactions to IM immune globulin. After premedication with cetirizine, prednisone and montelukast, the woman underwent desensitisation with SC 16% immune globulin 10g (163 mg/kg) infused over 4.5 hours. After the second infusion, premedication was discontinued. She received three more SC infusions inoffice, followed by weekly at-home infusions of immune globulin 10g over 1.5 hours. After 16 months of treatment, she was switched to SC 20% immune globulin [Hizentra] 10 g/week with no adverse effects. Prince T, et al. Desensitization Approach Using High-Concentration Subcutaneous Immunoglobulin in a Bruton’s-Like Patient With a Previous Anaphylactic Reaction to Intravenous Immunoglobulin. 68th Annual Meeting of the American Academy of Allergy, Asthma and Immunology : abstr. 62, 3 Mar 2012. Available from: 803069757 URL: http://annualmeeting.aaaai.org - USA
0114-9954/10/1400-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 5 May 2012 No. 1400
Data Loading...
