Immune globulin
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Acute renal failure due to sucrose excipient: case report In a retrospective study involving patients treated with immune globulin in a Paediatric Infectious Diseases Clinic between October 2010 and May 2015, one patient [age and sex not stated] was described, who developed acute renal failure during treatment with immune globulin. The ADR was attributed to sucrose, an excipient used in immune globulin preparation. The patient was admitted and received treatment with IV infusion of immune globulin [immunoglobulin; dosage and indication not stated]. Prior to the immune globulin therapy, the patient received pheniramine [Avil; pheniramine maleate] and paracetamol to reduce side effects. However, the patient developed acute renal failure as a delayed side effect of immune globulin. The acute renal failure was considered to be related to the excipient of immune globulin, sucrose. The patient was treated with IV hydration, following which normalisation of renal function was observed. Author comment: "Acute renal failure develops as a result of tubular damage caused by solid load of sucrose used in [IV immune globulin] preparations." "Delayed side effects were . . . acute renal failure in one patient". Aydin ZGG, et al. Clinical indications of intravenous immunoglobulin use in pediatric infectious diseases clinic. Cocuk Enfeksiyon Dergisi 11: e148-e153, No. 4, Dec 2017. Available from: URL: http://doi.org/10.5578/ced.201741 803439794 Turkey
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Reactions 14 Dec 2019 No. 1783
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