Incidence and risk factors for fluorescence abnormalities on near-infrared imaging using indocyanine green in stapled fu
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ORIGINAL ARTICLE
Incidence and risk factors for fluorescence abnormalities on near-infrared imaging using indocyanine green in stapled functional end-to-end anastomosis in laparoscopic colectomy Hiroki Ohya 1 & Jun Watanabe 1 & Hirokazu Suwa 2 & Yusuke Suwa 1 & Atsushi Ishibe 3 & Hidenobu Masui 2 & Kaoru Nagahori 2 & Chikara Kunisaki 1 & Itaru Endo 3 Accepted: 17 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Recently, several studies have suggested that near-infrared (NIR) imaging using indocyanine green (ICG) may contribute to the reduction of anastomotic leakage (AL) after colorectal cancer (CRC) surgery. However, few reports have focused on the usefulness of NIR imaging for AL after stapled functional end-to-end anastomosis (stapled FEEA). The purpose of this study was to clarify the frequency of fluorescence abnormalities on NIR imaging, in cases reconstructed with stapled FEEA. Methods This retrospective study included patients with colon or appendiceal cancer who underwent laparoscopic colectomy with stapled FEEA reconstruction between March 2016 and August 2019. Results A total of 400 patients who were managed at our three institutions were included in the present study. The rate of Clavien-Dindo (CD) grade > III AL was 1.0% (4/400). The median length of postoperative hospital stay was 7 days (IQR 25– 75th percentile 6–8 days). In 11 patients (2.8%), the transection line was changed by NIR imaging, due to fluorescence abnormalities. The rate of transverse colon involvement in anastomosis was significantly higher in cases with fluorescence abnormalities than in cases with normal fluorescence (p = 0.035). Conclusions The frequency of fluorescence abnormalities on NIR was 2.8% in cases of colon resection with reconstruction by using stapled FEEA. There was a probability of abnormal fluorescence on NIR in cases where the transverse colon was involved in the anastomosis. This means that NIR may have potential benefit in such cases. Trial registration UMIN000039977 Keywords Near infrared . Indocyanine green . Colorectal surgery . Anastomotic leak . Functional end-to-end anastomosis
Introduction Colorectal cancer (CRC) is the third most common cancer worldwide [1]. Surgery is a radical treatment for advanced This study was not been presented previously. * Jun Watanabe [email protected] 1
Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, 4-57, Urafune-cho, Minami-ku, Yokohama 232-0024, Japan
2
Department of Surgery, Yokosuka Kyosai Hospital, Yokosuka, Japan
3
Department of Gastroenterological Surgery, Graduate School of Medicine, Yokohama City University, Yokohama, Japan
CRC, and it plays a central role in the combined modality therapy for CRC. Anastomotic leakage (AL) after CRC surgery is one of the most serious complications. Several previous studies have revealed that once AL occurs in CRC surgery, it affects not only the short-term outcomes but also the long-term outcomes [2]. Although various measures for prevent
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