Insights into Receptor Function and New Drug Development Targets
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory p
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M. Conn C. Kordon Y. Christen (Eds.)
Insights into Receptor Function and New Drug Development Targets With 58 Figures and 14 Tables
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Conn, Michael, Ph.D. Divisions of Neuroscience and Reproductive Biology Departments of Physiology and Pharmacology and Cell and Developmental Biology 505 NW 185th Avenue Oregon National Primate Research Center Oregon Health and Science University Beaverton, Oregon 97006 USA email: [email protected] Kordon, Claude, Ph.D. Institut Necker 156, rue de Vaugirard 75015 Paris France e-mail: [email protected]
Christen, Yves, Ph.D. Fondation IPSEN Pour la Recherche Thérapeutique 24, rue Erlanger 75781 Paris Cedex 16 France e-mail: [email protected]
ISBN-10 3-540-34446-2 Springer Berlin Heidelberg New York ISBN-13 978-3-540-34446-9 Springer Berlin Heidelberg New York Cataloging-in-Publication Data applied for Bibliographic information published by Die Deutsche Bibliothek Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie; detailed bibliographic data is available in the Internet at . This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permissions for use must always be obtained from Springer. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: design & production, Heidelberg, Germany Typesetting and production: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig, Germany Printed on acid-free paper 27/3100/YL 5 4 3 2 1 0 SPIN 11757955
Introduction
“You cannot suppose that atoms of the same shape are entering our nostrils when stinking corpses are roasting as when the stage is freshly sprinkled with saffron of Cilicia and a near-by alter exhales the perfumes of the Orient. You cannot attribute the same composition to sights that feast the eye with colour and to those that make it smart and weep or that appear loathsome and repulsive through sheer ugliness. Nothing that gratifies the sense is ever without a certain smoothness of the constituent atoms. Whatever, on the other hand, is painful and harsh is character
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