Interleukin-15 and creatine kinase response to high-intensity intermittent exercise training
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ORIGINAL ARTICLE
Interleukin‑15 and creatine kinase response to high‑intensity intermittent exercise training Thaislaine dos Santos1 · Fabio Santos Lira1 · Barbara Moura Antunes1 Received: 3 September 2019 / Accepted: 19 February 2020 © Springer-Verlag Italia S.r.l., part of Springer Nature 2020
Abstract Purpose To verify the acute and chronic effects of high-intensity intermittent training (HIIT) on interleukin 15 (IL-15) response and the relationship between circulating IL-15 concentrations and muscle damage in young men. Methods Physically active men performed two different training protocols at moderate and high intensity, three times per week for 5 weeks. Twenty subjects were randomly allocated into high-intensity intermittent training group (HIIT-5 km 1 min at 100% of maximal aerobic speed interspersed by 1 min passive recovery; n = 10) or moderate-intensity continuous training group (MICT-5 km 70% of maximal aerobic speed; n = 10). An acute exercise session was performed with blood sample collection pre-exercise, immediately post-exercise, and 60 min post-exercise (before and after 5 weeks of training). Blood samples were used to analyze serum IL-15 and creatine kinase (CK) concentrations. Results The results showed no changes in serum IL-15 concentrations independent of protocol, moment measurement, and intervention period. CK concentrations showed higher values post-exercise when compared to pre-exercise in both protocols. No significant relationship was found between serum IL-15 and CK concentrations. Conclusion Our findings point to the absence of acute and chronic changes in serum IL-15 concentrations in response to 5 weeks of high-intensity intermittent training. In addition, data suggest that the release of this cytokine is not related to muscle damage in healthy young men. Keywords Cytokines · Exercise training · Metabolism · Inflammation · Interleukins
Introduction The endocrine function of skeletal muscle through synthesis and release of several myokines is well documented, especially interleukins (IL) as IL-6, IL-8, and IL-15 [1]. IL-15 is secreted by skeletal muscle and exerts autocrine and paracrine effects on skeletal muscle metabolism, such as anabolic function in muscle growth (increased myogenesis and decreased protein degradation)[2], as well as ,enhancing glucose uptake and lipid oxidation, promoting homeostasis of the circulating energy substrates throughout the body * Thaislaine dos Santos [email protected] * Fabio Santos Lira [email protected] 1
Exercise and Immunometabolism Research Group, Department of Physical Education, School of Technology and Sciences, São Paulo State University (Unesp), Presidente Prudente, São Paulo, Brazil
[3]. However, in the literature, the endocrine effects of this myokine are not yet clear and some hypotheses have been raised [4]. Although there are studies in the literature which investigated the effects of physical exercise on IL-15 response, these mostly used resistance exercise and the findings using aerobic exercise
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