Linezolid
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Acquired drug resistance: 13 case reports In a retrospective study of 39 patients, 13 patients [ages and sexes were not stated] were described, who developed acquired resistance during treatment with linezolid for tuberculosis (TB). The adult patients, who were diagnosed with TB, had been receiving linezolid daily [routes and doses not stated] for 8–26 months. Sanger sequencing (targeted sequencing) was performed with the isolates obtained at linezolid minimum inhibitory concentration (MIC) ranging between 2–8 mg/L, including two isolates with no growth. Phenotypic resistance associated with resistance mutations due to the T460C substitution in rplC (n=7) and G2814T [2576] (n=3), G2270C [2032](n=1), G2270T [2032] (n=1) and A2810C [1942] (n=1) substitutions in rrl along with predominant WT alleles were noted. The findings were suggestive of acquired resistance to linezolid. Wasserman S, et al. Linezolid resistance in patients with drug-resistant TB and treatment failure in South Africa. Journal of Antimicrobial Chemotherapy 74: 2377-2384, No. 803501867 8, Aug 2019. Available from: URL: http://doi.org/10.1093/jac/dkz206
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Reactions 19 Sep 2020 No. 1822
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