Microdomains in the Cardiovascular System

The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offe

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Viacheslav Nikolaev Manuela Zaccolo Editors

Microdomains in the Cardiovascular System

Cardiac and Vascular Biology Editor-in-chief Markus Hecker Inst. of Physiology & Pathophysiology, Heidelberg University, Heidelberg, Germany Series Editor Johannes Backs Department of Cardiology, Heidelberg University, Heidelberg, Germany Marc Freichel Institute of Pharmacology, Heidelberg University, Heidelberg, Germany Thomas Korff Inst. of Physiology & Pathophysiology, Heidelberg University, Heidelberg, Germany Dierk Thomas Department of Internal Medicine III, Heidelberg University Hospital, Heidelberg, Germany

The book series gives an overview on all aspects of state-of-the-art research on the cardiovascular system in health and disease. Basic research aspects of medically relevant topics are covered and the latest advances and methods covering diverse disciplines as epigenetics, genetics, mechanobiology, platelet research or stem cell biology are featured. The book series is intended for researchers, experts and graduates, both basic and clinically oriented, that look for a carefully selected collection of high quality review articles on their respective field of expertise. More information about this series at http://www.springer.com/series/13128

Viacheslav Nikolaev • Manuela Zaccolo Editors

Microdomains in the Cardiovascular System

Editors Viacheslav Nikolaev Institute of Experimental Cardiovascular Research University Medical Center Hamburg-Eppendorf Germany

Manuela Zaccolo Department of Physiology, Anatomy and Genetics University of Oxford Oxford United Kingdom

ISSN 2509-7830     ISSN 2509-7849 (electronic) Cardiac and Vascular Biology ISBN 978-3-319-54578-3    ISBN 978-3-319-54579-0 (eBook) DOI 10.1007/978-3-319-54579-0 Library of Congress Control Number: 2017952370 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliation