microRNA: Medical Evidence From Molecular Biology to Clinical Pract

This volume explores microRNA function in a wide array of human disorders, providing a clinical basis for precision medicine and personalized therapies using these molecules. The twenty-one chapters, all authored by internationally-renowned experts, open

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Gaetano Santulli Editor

microRNA: Medical Evidence From Molecular Biology to Clinical Practice

Advances in Experimental Medicine and Biology Volume 888 Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy

More information about this series at http://www.springer.com/series/5584

Gaetano Santulli Editor

microRNA: Medical Evidence From Molecular Biology to Clinical Practice

Editor Gaetano Santulli Columbia University Medical Center New York, NY, USA

ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-319-22670-5 ISBN 978-3-319-22671-2 (eBook) DOI 10.1007/978-3-319-22671-2 Library of Congress Control Number: 2015955613 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

Foreword

It gives me immense pleasure to introduce microRNA: Medical Evidence—From Molecular Biology to Clinical Practice to the medical and scientific community. The book you are holding was developed to provide medical students, researchers, and physicians with the knowledge on an emerging fundamental section of biomedicine: microRNA. This book represents one volume—focused on clinical practice—of a trilogy exploring the functional role of microRNAs from basic science to the clinical scenario. The other two volumes explore the importance of microRNA in molecular biology and in cancer, respectively. The books have been edited by Dr. Gaetano Santulli, MD, PhD, who reunited the major experts in the microRNA field in order to have a comprehensive, up-to-date, and systematic overview of the mechani