Molecularly Imprinted Au Nanoparticle Composites for Selective Sensing Applications
In this study, a new method to imprint molecular recognition sites into Au nanoparticles (NPs) composites is described. The method includes the electropolymerization of thioaniline-functionalized Au NPs in the presence of imprint substrates that exhibit a
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Abstract In this study, a new method to imprint molecular recognition sites into Au nanoparticles (NPs) composites is described. The method includes the electropolymerization of thioaniline-functionalized Au NPs in the presence of imprint substrates that exhibit affinity interactions with the thioaniline-functionalized Au NPs or with a co-added ligand associated with the electropolymerizable NPs. Exclusion of the imprint substrate from the composite leads to the formation of selective imprinted sites in the Au NPs matrices. The imprinted matrices are implemented for the sensing of explosives, herbicides, saccharides, and ions. p-Donor–acceptor interactions, ionic interactions and H-bonds, or ligand–substrate interactions are used to generate the imprinted sites. The coupling between the localized plasmon of the NPs and the surface plasmon wave of the support is used to amplify the dielectric changes occurring in the NPs matrices upon the binding of the analytes to the imprinted sites, thus enabling the surface plasmon resonance (SPR) transduction of the sensing events. The imprinted Au NPs matrices demonstrate highly selective, stereoselective, and chiroselective sensing performance. Keywords Electropolymerization, Molecular imprinting, Nanoparticles, Sensors, Surface plasmon resonance
Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Molecularly Imprinted Bis-Aniline-Cross-linked Au NPs Matrices for Sensing . . . . . . . . . 2.1 Molecular Imprinting of Recognition Sites in Au NPs Composites Through Donor–Acceptor Interactions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 Ionic Interactions in Molecularly Imprinted Au NPs Matrices for Sensing . . . . . . . .
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R. Tel-Vered and I. Willner (*) The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel e-mail: [email protected] S.A. Piletsky and M.J. Whitcombe (eds.), Designing Receptors for the Next Generation of Biosensors, Springer Series on Chemical Sensors and Biosensors (2013) 12: 189–212 DOI 10.1007/5346_2012_18, # Springer-Verlag Berlin Heidelberg 2012, Published online: 27 June 2012
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2.3 Imprinted Electropolymerized Au NPs Composites Based on Ligand–Analyte Complexation Processes for Sensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 3 Conclusions and Perspectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 208 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
1 Introduction During the past several decades, and in accord with the rapidly growing field of nanotechnology, a considerable amount
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