MRI detects coronary vessel wall thickening with age in healthy subjects
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MRI detects coronary vessel wall thickening with age in healthy subjects Andrew D Scott1*, Jennifer Keegan2, Raad H Mohiaddin2, David N Firmin1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Objective To investigate the effects of ageing on the coronary vessel wall of healthy subjects using MR. Background Autopsy studies [1,2] and x-ray CT in older subjects with suspected disease [3] have demonstrated increasing coronary vessel thickness with age. There is, however, a need for a radiation-free non-invasive technique for use in longitudinal studies of coronary vessel wall morphology. Recently 3D MR coronary vessel wall imaging with retrospective beat-to-beat respiratorymotion-correction (B2B-RMC)[4], which uses 3D low resolution data acquired immediately before the main imaging data to retrospectively correct respiratory motion, has demonstrated great promise [5]. We propose that 3D high resolution MR with B2B-RMC can
demonstrate coronary vessel wall thickening with age in healthy subjects.
Methods 21 healthy subjects with no history of cardiovascular disease (mean age 39±13, range 22-62, 11 female) were recruited. Studies were performed on a 1.5T Siemens Avanto scanner. Cross-sectional vessel wall imaging was performed in the proximal right coronary artery (
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