Multidimensional Analysis of Risk Factors for the Severity and Mortality of Patients with COVID-19 and Diabetes
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ORIGINAL RESEARCH
Multidimensional Analysis of Risk Factors for the Severity and Mortality of Patients with COVID19 and Diabetes Juan Huang . Lin Zhu . Xiangli Bai . Xiong Jia . Yajing Lu . Aiping Deng . Juyi Li . Si Jin
Received: August 20, 2020 / Accepted: September 23, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: Diabetes is one of the most common comorbidities of COVID-19. We aimed to conduct a multidimensional analysis of risk factors associated with the severity and mortality of patients with COVID-19 and diabetes. Methods: In this retrospective study involving 1443 patients with COVID-19, we analyzed the clinical and laboratory characteristics and risk Juan Huang and Lin Zhu contributed equally to this work.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s40121020-00359-6) contains supplementary material, which is available to authorized users. J. Huang X. Jia S. Jin (&) Department of Endocrinology, Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei, China e-mail: [email protected] J. Huang Department of Personnel, Department of Nephrology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei, China L. Zhu Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei, China
factors associated with disease severity in patients with COVID-19 with and without diabetes. Binary logistic regression analyses were performed to identify the risk factors associated with mortality in patients with COVID-19 and diabetes. The 84-day survival duration for critical patients with COVID-19 and diabetes who had different levels of leukocytes and neutrophils, or treated with immunoglobulin or not, was conducted using Kaplan–Meier survival curves. Results: Of the 1443 patients with COVID-19, 256 (17.7%) had diabetes, had a median age of 66.0 [IQR 58.0–73.8] years, and were more likely to develop severe (41.8% vs. 35.6%) and critical disease (34.0% vs. 14.9%), followed by higher mortality (21.1% vs. 7.0%), than those without diabetes. Higher levels of leukocytes X. Bai Department of Laboratory Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei, China Y. Lu Institute of Geriatric Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei, China A. Deng J. Li Department of Pharmacy, Key Laboratory for Molecular Diagnosis of Hubei Province, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
Infect Dis Ther
([ 5.37 9 109/L), older age, and comorbid cerebrovascular disease and chronic renal disease independently contributed to in-hospital death of patients with COVID-19 and diabetes. Leukocytes [ 5.37 9 109/L and the application of immunoglobulin wer
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