Naproxen
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Drug reaction with eosinophilia and systemic symptoms (DRESS): case report A 22-year-old woman developed drug reaction with eosinophilia and systemic symptoms (DRESS) during treatment with naproxen for mechanical dorsal pain. The woman received naproxen for mechanical dorsal pain [dosage and route not stated]. After 5 days, she developed dyspnoea and a skin eruption. Chest radiography revealed bilateral pleural effusion and multi-lobar consolidations. Laboratory investigations revealed eosinophilia absolute count of 1780 and hypertransaminasaemia, which indicated acute liver failure. Her dyspnoea progressed and a chest CT was performed which revealed pericardial and pleural effusions, peribroncovascular consolidations, diffuse centrilobular nodules and axillary and mediastinal adenomegalies. A diagnosis of eosinophilic pneumonia was performed. The Registry of Severe Cutaneous Adverse Reactions score was 7, which confirmed a definitive diagnosis of DRESS. The woman was treated with systemic steroids. Lung and liver alterations resolved gradually. Guerrero Gomez DA, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement. Radiology Case Reports 15: 803504066 2178-2182, No. 11, Nov 2020. Available from: URL: http://doi.org/10.1016/j.radcr.2020.08.037
0114-9954/20/1824-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 3 Oct 2020 No. 1824
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