NICU acute kidney injury with nephrotoxic drug combinations
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NICU acute kidney injury with nephrotoxic drug combinations For patients in neonatal intensive care units (NICUs) exposed to nephrotoxic drug combinations, a longer duration of combination therapy was associated with an increased risk of acute kidney injury (AKI), according to study results reported in the Journal of Pediatrics, "regardless of the nephrotoxic drug administered". The study used a large database from 268 NICUs managed by the Pediatrix Medical Group, and excluded infants who were predisposed to AKI. There were 8286 neonates of ≤120 days postnatal age who had been born at 22–36 weeks of gestation and had been exposed to only one nephrotoxic drug combination, with both drugs given on the same day. AKI occurred in 1364 neonates (17%), diagnosed as stage 1, 2 or 3 in 11%, 4% and 2% of patients, respectively. In a logistic model, longer duration of combination therapy, lower baseline creatinine level, and sepsis were associated with an increased AKI risk. In a Cox model, those factors along with birth weight
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