Nile Tilapia Fish Skin, Scales, and Spine as Naturally Derived Biomaterials for Tissue Regeneration
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DENTAL RESTORATIVE MATERIALS (M ÖZCAN & P CESAR, SECTION EDITOR)
Nile Tilapia Fish Skin, Scales, and Spine as Naturally Derived Biomaterials for Tissue Regeneration Maria Elisa Quezado Lima-Verde 1,2 & S. Prakash Parthiban 3 & Antonio Ernando Carlos Ferreira Junior 1,2 & Paulo Goberlânio de Barros Silva 1,2 & Edmar Maciel Lima Junior 4 & Manoel Odorico de Moraes 2 & Vicente de Paulo Aragão Sabóia 1 & Luiz E. Bertassoni 3,5,6,7 & Ana Paula Negreiros Nunes Alves 1,2 Accepted: 20 July 2020 # Springer Nature Switzerland AG 2020
Abstract Purpose of Review This study aims to review the literature on the use of Nile tilapia-derived extracellular matrix (ECM) proteins as naturally derived scaffold material for tissue regeneration. Recent Findings Nile tilapia has emerged as a particularly relevant specie for the development of fish-derived biomaterials. The skin, scale, and spine of various fish species have been extensively demonstrated as a potential source of native ECM proteins for use in regenerative medicine. Summary When compared to synthetic polymers, collagen-based biomaterials introduce some disadvantages due to their lower biomechanical stiffness and rapid biodegradation. However, collagen-based biomaterials continue to be one of the most highly investigated natural materials for bone regeneration. Studies have pointed to tilapia as a satisfactory source of collagen for its quality and cost benefit, with good responses in vitro and in vivo, especially studies involving the skin as the main source of production. For both soft and hard tissue regenerations, Nile tilapia skin is being considered as a good source of collagen. Other sources (scales and spine) are less addressed in comparison to skin, which in turn, brings more consistent perspective in relation to clinical use. Keywords Tilapia . Scaffold . Regeneration . Tissue engineering
Introduction Tissue engineering and regenerative medicine are interdisciplinary fields that aim at finding effective treatment solutions for various diseases and conditions. Since their establishment
as specialized areas of biomedical research, a consistent focus in the field has been the development of technologies to mimic the native extracellular matrix of tissues and organs, allowing for the control of cell function and guided tissue growth and regeneration [1]. Scaffold-based biomaterials are vital in these
This article is part of the Topical Collection on Dental Restorative Materials * Luiz E. Bertassoni [email protected] 1
Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing (FFOE), Federal University of Ceará (UFC), Monsenhor Furtado, s/n, Rodolfo Teofilo, Fortaleza, CE 60430-160, Brazil
2
Drug Research and Development Center (NPDM), Federal University of Ceará (UFC), Fortaleza, CE, Brazil
3
Division of Biomaterials and Biomechanics, Department of Restorative Dentistry, School of Dentistry, Oregon Health and Science University, 6N005, 2730 S.W. Moody Ave, Portland, OR 97201, USA
4
Doctor José Frota Institute (IJF), Fortaleza, Ceará, Bra
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