Polycomb Group Proteins Methods and Protocols
This volume presents the most recent technologies used in the Polycomb Group Proteins (PcG) field. Chapters detail state-of-the-art methods, creating a unique and comprehensive reference source for investigating Polycomb function in the nucleus. Wri
- PDF / 10,717,571 Bytes
- 321 Pages / 504.63 x 737.01 pts Page_size
- 26 Downloads / 192 Views
Chiara Lanzuolo Beatrice Bodega Editors
Polycomb Group Proteins Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Polycomb Group Proteins Methods and Protocols
Edited by
Chiara Lanzuolo IBCN-CNR, Institute of Cell Biology and Neurobiology and Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”, Rome, Italy
Beatrice Bodega Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi”, Milan, Italy
Editors Chiara Lanzuolo IBCN-CNR Institute of Cell Biology and Neurobiology and Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi” Rome, Italy
Beatrice Bodega Istituto Nazionale di Genetica Molecolare “Romeo ed Enrica Invernizzi” Milan, Italy
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6378-2 ISBN 978-1-4939-6380-5 (eBook) DOI 10.1007/978-1-4939-6380-5 Library of Congress Control Number: 2016948855 © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface Investigating the Polycomb Group of Proteins: Technologies à la Carte In eukaryotic cells, genomic DNA is packaged in a highly regulated conformation inside the nucleus. This ordered shape consists of multiple levels of epigenetic regulation resulting from dynamic interactions between the genome, chromatin modifiers, and various species of noncoding RNAs. The overall set of DNA, histone modification, and chromatin regulators define an epigenome, which is cell specific and regulates the transcriptome, determining the cell identity (reviewed in [1]). The Polycomb group of proteins (PcG proteins) is one of the most studied families of transcri
Data Loading...
