Propofol
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Propofol infusion syndrome in paediatric patients: 2 case reports During heart surgery, two girls, aged 12 and 16 years, received infusions of propofol [dosages not clearly stated] for general anaesthesia induction and maintenance. After surgery, they were transferred to an ICU and received continuous IV propofol for sedation. Both girls then developed progressive metabolic acidosis [times to reaction onsets not clearly stated]. Despite administration of sodium bicarbonate, the girls’ lactate levels continued to increase and reached maximum levels of 9.3 mmol/L and 14.7 mmol/L , respectively. Propofol infusion syndrome was considered and propofol, which had been infused at < 3 mg/kg/h, was discontinued after 15 and 8 hours in the two girls, respectively. Metabolic acidosis subsequently gradually resolved and both girls recovered. Author comment: "Our hypothesis that the observed lactic acidosis indicates an early stage of [propofol infusion syndrome] is sustained by some arguments, especially including: absence of other usual causes for lactic acidosis, close association with propofol infusion, and quick reversibility of acidosis without specific intervention upon cessation of propofol infusion." Laquay N, et al. Early stages of propofol infusion syndrome in paediatric cardiac surgery: two cases in adolescent girls. British Journal of Anaesthesia 101: 880-881, 801124750 No. 6, Dec 2008 - France
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Reactions 22 Nov 2008 No. 1229
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