Prostacyclin and Its Stable Analogue Iloprost
Ten years after the discovery of prostacyclin, our knowledge of its biochemical mode of action, pharmacological properties, pathophysiological significance and therapeutic applications is ever expanding. Prostacyclin is both complex and unique as demonstr
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VVith 131 Figures and 48 Tables
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Professor Dr. R. J. Gryglewski Copernicus Academy of Medicine Department of Pharmacology 16 Grzegorzecka 31531 Cracow, Poland
Professor Dr. med. G. Stock Schering AG Cardiovascular Pharmacology MUllerstraBe 170-178, 1000 Berlin 65, FRG
Proceedings of the First International Workshop on Iloprost Bad Kissingen, November 7-9, 1985
Cover: Structural formula and Van-der-Waals surface of prostacyclin (bottom) and of Iloprost (middle and top), depicted with the TRIPOS "SYBYL" programme on a DIGITAL EQUIPMENT "VAX" on a EVANS and SUTHERLAND PS 300
Library of Congress Cataloging in Publication Data. International Workshop on Iloprost (1st: 1985: Bad Kissingen, Germany) Prostacyclin and its stable analogue Iloprost. "Proceedings of the First International Workshop on Iloprost, Bad Kissingen, November 7-9, 1985"-T.p. verso. Includes indexes. 1. Prostacyclin- Therapeutic use-Congresses. 2. Prostacyclin-Congresses. I. Gryglewski, Ryszard. II. Stock, G. (Giinter) III. Title. [DNLM: 1. Prostaglandins X-congresses. W3 IN9325S 1st 1985p/QW 90 16138 1985p) ISBN-13: 978-3-642-71501-3 DOT: 10.1007/978-3-642-71499-3
e-ISBN-13: 978-3-642-71499-3
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Preface
Ten years after the discovery of prostacyclin, our knowledge of its biochemical mode of action, pharmacological properties, pathophysiological significance and therapeutic applications is ever expanding. Prostacyclin is both complex and unique as demonstrated by its unusual feature of being chemically and metabolically unstable when compared to other prostanoids and known amine or peptide mediators. Although physiologically essential, the chemical instability of prostacyclin poses a serious drawback in laboratory and clinical studies. It is one of the genuine objectives of pharmaceutical research to supply synthetic compounds which overcome the inherent drawbacks - considering investigational and therapeutic use - of endogenous compounds. Whereas metabolic instab
