Quantitative perfusion-CMR is significantly influenced by the placement of the arterial input function
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ORIGINAL PAPER
Quantitative perfusion-CMR is significantly influenced by the placement of the arterial input function Ibnul Mia1,3 · Melanie Le1 · Christophe Arendt1 · Diana Brand1 · Sina Bremekamp1 · Tommaso D’Angelo2 · Valentina O. Puntmann1 · Eike Nagel1,3 Received: 6 July 2020 / Accepted: 26 September 2020 © The Author(s) 2020
Abstract The aim of this study is to provide a systematic assessment of the influence of the position on the arterial input function (AIF) for perfusion quantification. In 39 patients with a wide range of left ventricular function the AIF was determined using a diluted contrast bolus of a cardiac magnetic resonance imaging in three left ventricular levels (basal, mid, apex) as well as aortic sinus (AoS). Time to peak signal intensities, baseline corrected peak signal intensity and upslopes were determined and compared to those obtained in the AoS. The error induced by sampling the AIF in a position different to the AoS was determined by Fermi deconvolution. The time to peak signal intensity was strongly correlated (r2 > 0.9) for all positions with a systematic earlier arrival in the basal (− 2153 ± 818 ms), the mid (− 1429 ± 928 ms) and the apical slice (− 450 ± 739 ms) relative to the AoS (all p 0.9 for both) for all positions with a systematic overestimation in all positions relative to the AoS (all p
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