RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal T
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Cite as Nano-Micro Lett. (2020) 12:94 Received: 15 January 2020 Accepted: 28 February 2020 © The Author(s) 2020
https://doi.org/10.1007/s40820-020-00429-x
RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near‑Infrared Photoacoustic Imaging and Photothermal Therapy Dongye Zheng1,2,3, Peiwen Yu2,4, Zuwu Wei2,4, Cheng Zhong5, Ming Wu2,4 *, Xiaolong Liu1,2,3,4 * Dongye Zheng and Peiwen Yu have been contributed equally to this work. * Ming Wu, [email protected]; Xiaolong Liu, [email protected] School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, People’s Republic of China
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The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People’s Republic of China Mengchao Med‑X Center, Fuzhou University, Fuzhou 350116, People’s Republic of China Department of Chemistry, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Wuhan University, Wuhan 430072, People’s Republic of China
HIGHLIGHTS • A narrow bandgap electron donor–acceptor (D–A) semiconducting polymer nanoparticle (SPN) coated with red blood cell membrane (RBCM) for photoacoustic imaging and photothermal therapy. • The D–A structure endows SPN with excellent near-infrared absorbance, high photothermal conversion ability, and good photothermal stability. • The RBCM endows SPN with good biocompatibility, prolonged blood circulation, and improved tumor accumulation, while the small size structure endows SPN with deep tumor penetration and rapid clearance from body. ABSTRACT Semiconducting conjugated
SPN
polymer nanoparticles (SPNs) represent an
400 nm
emerging class of phototheranostic materi‑
Extrusion
In this report, low-bandgap electron donor– acceptor (D–A)-conjugated SPNs with sur‑
therapy. The resulting RBCM-coated SPN
LUMO
R
lig
ht
Ex
S1 NI
S0
HOMO D
i.v.
bility, as well as high photothermal conver‑ sion efficiency for photoacoustic imaging and
sp
808 nm Laser
HOMO A
D-A
PTT PAI
(SPN@RBCM) displays remarkable nearinfrared light absorption and good photosta‑
n
ctio
inje
NRR
photoacoustic imaging and photothermal
LUMO Low band qap
(RBCM) are developed for highly effective
SPN@RBCM
(RBCM)
als with great promise for cancer treatment.
face cloaked by red blood cell membrane
200 nm
n
Donor (TTBTT) Acceptor (TBDOPV)
Long circulation
photothermal therapy. Particularly, due to the Vol.:(0123456789)
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(2020) 12:94
small size (
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