Regional coronary endothelial function is related to local coronary wall thickness in CAD patients using 3T MRI
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POSTER PRESENTATION
Open Access
Regional coronary endothelial function is related to local coronary wall thickness in CAD patients using 3T MRI Allison G Hays1*, Sebastian Kelle2, Glenn A Hirsch1, Jing Yu1, Harsh K Agarwal1, Gary Gerstenblith1, Matthias Stuber3, Robert G Weiss1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Background Coronary endothelial function (endoFx) is an important physiologic indicator of vascular function. Abnormal function is present in patients with established coronary disease (CAD) and was recently shown to relate to the severity of luminal stenosis.1 However, luminal stenosis occurs late in the process of atherosclerosis, and a the extent to which abnormal coronary endoFx occurs early in atherosclerosis and whether it is related to measures of early, non-stenotic atherosclerosis, such as coronary wall thickness (CWT) are not known. Recent advances in MRI now allow non-invasive assessment of both anatomic (CWT) 2-4 and functional (endoFx) vascular properties that in the past required invasive studies, precluding evaluation of healthy subjects and low risk populations.
black-blood dual-inversion spiral imaging was used to quantify CWT and normalized wall index (NWI=lumen area/total area).
Results The stress-induced change in CSA was significantly higher in healthy adults (15.2%±11.0%, mean±SD) than in those with mild, non-stenotic CAD (-2.3%±7.4%, p
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