Regulatory Function of Adenosine Proceedings of the International Sy
The principal objective of this symposium was to bring together investigators from all over the world who work in diverse areas of research but share a common interest in the physiologic and pathophysiologic funetions of the nueleoside adenosine. In 1978,
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Developments in Pharmacology ather books in the series: J.M. Boeynaems and A.G. Herman, Prostaglandins, Proslacyclin, and Thromboxanes Measurement, 1980. ISBN 90 247 24171
REGULATORY FUNCTION OF ADENOSINE
PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON ADENOSINE, CHARLOTTESVILLE, VIRGINIA, JUNE 7-11,1982
edited by ROBERT M. BERNE Department of Physiology University of Virginia School of Medicine Charlottesville, Virginia, USA
THEODORE W. RALL Department of Pharmacology University of Virginia School of Medicine Charlottesville, Virginia, USA
RAFAEL RUBlO Department of Physiology University of Virginia School of Medicine Charlottesville, Virginia, USA
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1983 MARTINUS NIJHOFF PUBLISHERS BOSTON/THE HAGUEIDORDRECHT/LANCASTER
Copyright 1983 © by Martinus Nijhoff Publishers, The Hague Softcover reprint of the hardcover 1st edition 1983 All rights reserved. No part of this publieation may be reprodueed, stored in a retrieval system, or transmitted in any form or by any means, mechanieal, photoeopying, reeording, or otherwise, without written permission of the publisher, Martinus Nijhoff Publishers, P.O. Box 566, 2501 CN The Hague, The Netherlands. Distributors: for the United States and Canada
for all other Countries
Kluwer Boston, Inc. 190 Old Derby Street Hingham, MA 02043
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Library of Congress Cataloging in Publication Data
International Symposium on Adenosine (1982: Charlottesville, Va.) Regulatory funetion of adenosine. (Developments in pharmacology; v. 2) Indudes bibliographieal referenees. 1. Adenosine-Congresses. 2. Metabolie regulation-Congresses. I. Berne, Robert IV. Title. M. II. Rall, Theodore W. III. Rubio, Rafael, 1928QP625.A35157 1982 615'.7 82-18969 ISBN-13: 978-1-4613-3911-3 e-ISBN-13: 978-1-4613-3909-0 DOI: 10.1007/978-1-4613-3909-0
CONTENTS
List of Abstracts Vill Contributing Authors IX Preface xix Acknowledgments xxi I. ADENOSINE RECEPTORS
1. The complex structure and regulation of adenylate cyelase
3
MARTIN RODBELL
2. Adenosine receptors and adenylate cyelase interactions
17
CONSTANTINE LONDOS, J. WOLFF, DERMOT M.F. COOPER
3. Adenosine receptors on vascular smooth musele 33 RAY A. OLSSON
4. A com paris on of receptors for adenosine and adenine nueleotides 49 G. BURNSTOCK
5. General aspects of ligand-binding phenomena 63 THEODORE W. RALL
6. General aspects of binding of ligands to adenosine receptors
77
ULRICH SCHWABE
7. Binding of radioactive ligands to adenosine receptors in the central nervous system 97 JOHNW. DALY v
vi
Contents
II. ADENOSINE METABOLISM AND TRANSPORT
8. Regulation of adenosine metabolism by 5/ -nueleotidases
117
JOHN M. LOWENSTEIN, MING-KUN YU, YOSHITSUGO NAI TO
9. Metabolism of adenosine and sites of production in the heart 133 J. SCHRADER
10. Interaction of adenosine with adenosine-binding protein, S-adenosylhomocysteine hydrolase 157 PE
