Relationship of negative urgency to cingulo-insular and cortico-striatal resting state functional connectivity in tobacc
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ORIGINAL RESEARCH
Relationship of negative urgency to cingulo-insular and cortico-striatal resting state functional connectivity in tobacco use Miji Um 1
&
Tom A. Hummer 2 & Melissa A. Cyders 1
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Negative urgency, defined as a tendency to act rashly under extreme negative emotion, is strongly associated with tobacco use. Despite the robust evidence linking negative urgency and tobacco use and accumulating evidence suggesting that localized, segregated brain regions such as the nucleus accumbens (NAcc), insula, and amygdala are related to negative urgency, resting state functional connectivity (rsFC) of negative urgency in tobacco use has not yet been examined. This study included 34 daily tobacco users and 62 nonusers matched on age, gender, race/ethnicity, and lifetime psychiatric diagnosis from a publicly available neuroimaging dataset collected by the Nathan Kline Institute-Rockland Project. Using the bilateral NAcc, insula, and amygdala as seed regions, seedbased rsFC analyses were conducted on the whole brain. In the whole sample, negative urgency was positively correlated with rsFC between the left insula and right dorsal anterior cingulate cortex (dACC). Compared to non-users, tobacco users had a stronger rsFC strength between the right amygdala and right middle temporal gyrus. In tobacco users, negative urgency was negatively associated with rsFC between the left NAcc and right dACC and between the left NAcc and right dorsolateral prefrontal cortex; these relationships were positive in non-users. Identifying functional connectivity implicated in negative urgency and tobacco use is the crucial first step to design and test pharmacological and physiological interventions to reduce negative urgency related tobacco use. Keywords Negative urgency . Impulsivity . Tobacco use . Resting state functional connectivity . Cingulo-insular . Cortico-striatal
Introduction
Neural correlates of negative urgency
Negative Urgency, defined as the tendency to act rashly under extreme negative emotion (Cyders and Smith 2007; Whiteside and Lynam 2001), is one of five impulsivity traits in the UPPS-P model, the multidimensional model of impulsive personality traits. Negative urgency is related to addictive behaviors, such as tobacco use (e.g., Billieux et al. 2007; Doran et al. 2008, 2009; Lee et al. 2015), problematic alcohol use (e.g., Coskunpinar et al. 2013), and other drug use (e.g., Settles et al. 2012). Although well documented to be a robust risk factor for a wide range of addictive behaviors, and despite its clinical relevance, brain function underlying negative urgency is not yet well understood.
Neuroimaging studies of negative urgency highlight the importance of brain regions involved in reward, salience, and emotion processing, including the nucleus accumbens (NAcc), insula, and amygdala.
* Miji Um [email protected] 1
Department of Psychology, Indiana University – Purdue University Indianapolis, 402 N Blackford St, LD 124, Indianapol
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