Reviews of Physiology, Biochemistry and Pharmacology
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152 Physiology Biochemistryand Pharmacology Special Issue on Emerging Bacterial Toxins Edited by K. Aktories and I. Just
Editors S.G. Amara, Pittsburgh • E. Bamberg, Frankfurt R. Jahn, G6ttingen • W.J. Lederer, Baltimore A. Miyajima, Tokyo • H. Murer, Ztirich S. Offermanns, Heidelberg • G. Schultz, Berlin M. Schweiger, Berlin
With 57 Figures, 27 in color
Springer
Prof. Dr. Dr. Klaus Aktories Albert-Ludwigs-Universit~it Freiburg Institut ftir Experimentelle und Klinische Pharmakologie und Toxikologie Albertstr. 25 79104 Freiburg Germany E-mail: Klaus.Aktories @pharmakol.uni-freiburg.de Prof. Dr. Ingo Just Medizinische Hochschule Hannover Institut fiir Toxikologie Carl-Neuberg-Str. 1 30625 Hannover Germany E-mail: just.ingo @ mh-hannover.de
Library of Congress-Catalog-Card Number 74-3674 ISSN 0303-4240 ISBN 3-540-23131-5 Springer Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from SpringerVerlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2005 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Dr. Thomas Mager, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Andreas G6sling, Heidelberg Cover design: design & production GmbH, Heidelberg Typesetting: Stiirtz GmbH, Wtirzburg Printed on acid-free paper - 14/3150 ag
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Rev Physiol Biochem Pharmacol (2004) 152:1–22 DOI 10.1007/s10254-004-0034-4
K. Aktories · C. Wilde · M. Vogelsgesang
Rho-modifying C3-like ADP-ribosyltransferases
Published online: 15 September 2004 Springer-Verlag 2004
Abstract C3-like exoenzymes comprise a family of seven bacterial ADP-ribosyltransferases, which selectively modify RhoA, B, and C at asparagine-41. Crystal structures of C3 exoenzymes are available, allowing novel insights into the structure-function relationships of these exoenzymes. Because ADP-ribosylation specifically inhibits the biological functions of the low-molecular mass GTPases, C3 exoenzymes are established pharmacological tools to study the cellular
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