Selegiline ( l -Deprenyl) Mitigated Oxidative Stress, Cognitive Abnormalities, and Histopathological Change in Rats: Alt
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Selegiline (L-Deprenyl) Mitigated Oxidative Stress, Cognitive Abnormalities, and Histopathological Change in Rats: Alternative Therapy in Transient Global Ischemia Mahroo Ahmari 1,2 & Ali Sharafi 1,3 & Javad Mahmoudi 4 & Iraj Jafari-Anarkoli 5 & Mahmoud Gharbavi 3 & Mir-Jamal Hosseini 1,2 Received: 25 January 2020 / Accepted: 13 April 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Selegiline (L-deprenyl) is the major drug which is used in the treatment of Parkinson’s disease because of its neurotrophic and antiapoptotic properties. Previous studies suggested that low dose of L-methamphetamine (L-METH) caused lower mortality rate in patients with severe traumatic brain injury. As L-methamphetamine is one of the metabolites of selegiline, the present study aims to examine whether L-deprenyl can improve cognitive, biochemical, and histopathological injury in animal model of transient global ischemia. The animals were randomized in ten groups orally gavaged three times a week for 28 days. Then, novel object recognition (NOR) was conducted to assess their behavioral abnormality. After scarification of the rats, their brains were divided into two sections to measure oxidative stress parameters and perform pathological evaluations in rats. Our data revealed the involvement of oxidative stress, behavioral despair, and pathological data in transient global ischemia rats. Significant recovery in cognitive behavior, oxidative stress biomarker, and number of dead cell in histopathological assay was observed in rats treated with 1,2 and 4 mg/kg of selegiline. So, selegiline appears to be useful in alternative therapy of transient global ischemia. Keywords Behavioral abnormality . Transient global ischemia . Oxidative stress . Selegiline
Introduction Stroke as the most common neurological damage which suddenly and rapidly influences the brain has a harmful impact on patients’ health (Hachinski 2002). With at least five million deaths annually, it is a major cause of mortality worldwide which results in devastating disability problems (Bartolo * Mir-Jamal Hosseini [email protected] 1
Zanjan Applied Pharmacology Research Center, Zanjan University of Medical sciences, Zanjan, Iran
2
Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, P.O. Box: 45139-56184, Zanjan, Iran
3
Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
4
Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
5
Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
et al. 2015). In spite of the large body of investigations conducted in this field, no reliable and effective therapeutic strategy has been presented to prevent or minimize burden of stroke-related neuronal insults or improve the brain performance recovery after stroke, because various pathological factors are involved in biochemical cascade and neurological dysfunction
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