Sensing Tissue Damage by Myeloid C-Type Lectin Receptors
After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death. In addition, events of programmed cell death also take place under homeostatic conditions, such as in embryo development or in the tu
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Introduction.......................................................................................................................... Molecular Signatures Associated to Microorganisms and Self-damage ............................ Types of Cell Death ............................................................................................................ 3.1 Necrosis ...................................................................................................................... 3.2 Apoptosis .................................................................................................................... 3.3 Pyroptosis.................................................................................................................... 3.4 Necroptosis ................................................................................................................. 3.5 NETosis ...................................................................................................................... 3.6 Relevance of Oxidative Stress in Cell Death ............................................................ 4 C-Type Lectin Receptors in Myeloid Cells........................................................................ 4.1 DNGR-1 (CLEC9A)................................................................................................... 4.2 Mincle (CLEC4E)....................................................................................................... 4.3 Cll-1 (CLEC12A)........................................................................................................ 4.4 LOX-1 (OLR1) ........................................................................................................... 4.5 CD301 (CLEC10A) .................................................................................................... 4.6 Dec-205 (LY75) .......................................................................................................... 5 Conclusions.......................................................................................................................... References ..................................................................................................................................
Abstract After both sterile and infectious insults, damage is inflicted on tissues leading to accidental or programmed cell death. In addition, events of programmed cell death also take place under homeostatic conditions, such as in embryo development or in the turnover of hematopoietic cells. Mammalian tissues are seeded C. Del Fresno (&) F. J. Cueto D. Sancho (&) Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain e-mail: [email protected] D. Sancho e-mail: [email protected] Current Topics in Microbiology and Immunology https://doi.org/10.1007/82_2019_194 © Springer Nature Switzerland AG 2019
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with myeloid immune cells, which harbor a plethora of receptors that allow the detection of cell death, mod
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