Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive, Glaucoma
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ORIGINAL RESEARCH
Short-Term Steady-State Pattern Electroretinography Changes Using a Multi-Pressure Dial in Ocular Hypertensive, Glaucoma Suspect, and Mild OpenAngle Glaucoma Patients: A Randomized, Controlled, Prospective, Pilot Study Jeremy J. Kudrna
. Tanner J. Ferguson . Russell J. Swan .
Steven J. Ferguson . Brandon J. Baartman . Adam R. Bleeker . Ramu G. Sudhagoni . John P. Berdahl . Michael D. Greenwood Received: August 13, 2020 / Accepted: September 4, 2020 Ó The Author(s) 2020
ABSTRACT Introduction: This study evaluates the effects of the multi-pressure dial (MPD) on steady-state pattern electroretinography (ss-pERG) parameters. The study is a randomized, controlled, Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12911957. J. J. Kudrna (&) Department of Ophthalmology, Penn State College of Medicine, Hershey, PA, USA e-mail: [email protected] T. J. Ferguson Cole Eye Institute, Cleveland, OH, USA R. J. Swan Vance Thompson Vision, Bozeman, MT, USA S. J. Ferguson Dunes Eye Consultants, Dakota Dunes, SD, USA B. J. Baartman Vance Thompson Vision, Omaha, NE, USA A. R. Bleeker University of South Dakota Sanford School of Medicine, Sioux Falls, SD, USA R. G. Sudhagoni HemoSonics, LLC, Charlottesville, VA, USA J. P. Berdahl Vance Thompson Vision, Sioux Falls, SD, USA M. D. Greenwood Vance Thompson Vision, West Fargo, ND, USA
prospective, pilot trial in a private practice setting with ocular hypertensive (OHT), glaucoma suspect, and open-angle glaucoma (OAG) subjects. Methods: This study included nine patients (64 ± 9.0 years, nine female) with OHT, glaucoma suspect, or mild OAG. One eye of each subject was randomized to receive negative periocular pressure, while the contralateral eye served as the intrasubject control through the goggle without negative pressure. The Diopsys High Contrast Sensitivity ss-pERG protocol was conducted on both eyes of each subject while wearing the MPD device. Application of negative periocular pressure was set at 50% of baseline intraocular pressure for each study eye. Results: Following 2 h of negative periocular pressure application, the difference in MagnitudeD (MagD) from baseline for eyes randomized to receive negative periocular pressure (? 0.17 versus - 0.26) was statistically significant (p = 0.023). Over the same period, the change in MagD/Magnitude (MagD/Mag ratio) from baseline for eyes randomized to receive negative periocular pressure was also higher (? 0.14 versus - 0.16), compared to the control eyes, approached significance (p = 0.059). Conclusions: Following 2 h of MPD wear, the measured MagD and MagD/Mag ratio improved compared to control, suggesting that negative periocular pressure application to the anterior globe can lead to short-term improvement in one measure of retinal ganglion cell function.
Ophthalmol Ther
Keywords: Glaucoma management; Multipressure dial; Steady-state pattern electroretinogram Key Summary Points Glaucomatous diseases are a leading cause of blindness worldwide and c
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