Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body ad
- PDF / 836,430 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 64 Downloads / 130 Views
ORIGINAL ARTICLE
Strength training and aerobic exercise alter mitochondrial parameters in brown adipose tissue and equally reduce body adiposity in aged rats Anand Thirupathi 1,2 & Bruno Luiz da Silva Pieri 1 & João Annibal Milano Peixoto Queiroz 1 & Matheus Scarpatto Rodrigues 1 & Gustavo de Bem Silveira 1 & Daniela Roxo de Souza 1 & Thais Fernandes Luciano 1 & Paulo Cesar Lock Silveira 1 & Claudio Teodoro De Souza 3,4 Received: 19 September 2017 / Accepted: 23 January 2019 # University of Navarra 2019
Abstract With aging, there is a reduction in mitochondrial activity, and several changes occur in the body composition, including increased adiposity. The dysfunction of mitochondrial activity causes changes and adaptations in tissue catabolic characteristics. Among them, we can mention brown adipose tissue (BAT). BAT’s main function is lipid oxidation for heat production, hence playing a role in adaptive thermogenesis induced by environmental factors such as exercise. It is known that exercise causes a series of metabolic changes, including loss body fat; however, there is still no consensus in the academic community about whether both strength and aerobic exercise equally reduces adiposity. Therefore, this study aimed to evaluate the effects of strength training and aerobic exercise regimes on adiposity, proteins regulating mitochondrial activity, and respiratory complexes in BAT of old rats. The rats were divided in two control groups: young control (YC; N = 5), and old control (OC; N = 5), and two exercise groups: strength training (OST; N = 5), and aerobic treadmill training (OAT; N = 5). Rats were subjected to an 8-week exercise regime, and their body composition parameters were evaluated (total body weight, adiposity index, and BAT weight). In addition, mitochondrial biogenesis proteins (PGC-1α, SIRT1, and pAMPK) and respiratory chain activity (complexes I, II/III, III, and IV) were evaluated. Results showed that OST and OAT exercise protocols significantly increased the mitochondrial regulatory molecules and respiratory chain activity, while body fat percentage and adiposity index significantly decreased. Taken together, both OST and OAT exercise increased BAT weight, activity of respiratory complexes, and regulatory proteins in BAT and equally reduced body adiposity. Keywords Aging . Physical exercise . Brown adipose tissue . Adiposity . Metabolism
Abbreviations AMPK Adenosine monophosphate-activated protein kinase
BAT DTT EDTA NADH
* Claudio Teodoro De Souza [email protected]
NRF-1 NRF-2 OAT OC OST PGC-1α
1
Laboratory of Exercise Biochemistry and Physiology, Graduate Program in Health Sciences, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105 Bairro Universitário, Criciúma, Santa Catarina 88806-000, Brazil
2
Laboratory of Molecular Iron metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China
3
Department of Internal Medicine, Medicine School, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil
4
Programa de Pós-Graduação em S
Data Loading...
