Surgical stress detection in human blood plasma by DSC
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Surgical stress detection in human blood plasma by DSC Andrea Ferencz1 · Dénes Lőrinczy2 Received: 1 August 2019 / Accepted: 5 March 2020 © The Author(s) 2020
Abstract It is a well-known fact that the extension of the surgical intervention influences both the success and time of the patient’s recovery, the degree of the blood loss, i.e., overall the patients’ surgical burden. Disease itself determines extent of surgical procedure (minor, intermediate or major surgery), which affects the risk and frequency of complications. Previous works have contributed to the validation of differential scanning calorimetry (DSC) as a potential non-invasive tool for diagnosing and monitoring several illnesses. Hence, the main goal of this study was to measure the effect of each surgical intervention on its own to blood plasma composition. Peripheral venous blood samples were collected from patients who underwent minor (n = 8), intermediate (n = 9) and major surgical interventions (n = 7). According our DSC data of blood plasma components, from the thermodynamic parameters, namely from the thermal transitions (Tm1–Tm8) to calorimetric enthalpy (ΔHcal) in proportion corresponded to the size of surgical interventions (duration of operation time, length of incision, surgical intraoperative stress, blood loss, etc.). This examination has shown that intraoperative stress during any surgical intervention affects the composition of plasma proteins, which should be always considered in the evaluation of DSC results in any surgical study. Keywords Intraoperative stress · Minor surgery · Intermediate surgery · Major surgery · DSC · Blood plasma
Introduction Risk of operation depends on the extent of the surgical intervention, the burden of anesthesia and the comorbidities. Definition of surgical stress, namely an operative intervention is major, or minor have been arisen for the first time in 1917 during a correspondence between Dr. Robert Earl and his patient, Mr. Lewis S. Pilcher, which is published in the American scientific literature [1]. The question was as follows: “Define what is meant by minor surgery and what is meant by major surgery?” The answer is still in place today, and it is invariably true: accordingly “I would say that major surgery includes all work requiring a general anesthetic; all operations which involve openings into the great cavities of
* Andrea Ferencz [email protected] Dénes Lőrinczy [email protected] 1
Department of Surgical Research and Techniques, Faculty of Medicine, Semmelweis University, Nagyvárad Sqr. 4, Budapest 1089, Hungary
Institute of Biophysics, Medical School, University of Pécs, Szigeti Str. 12, Pecs 7624, Hungary
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the body; all operations in the course of which hazards of severe hemorrhage are possible; all conditions in which the life of the patient is at stake; all conditions which require for their relief manipulations, for the proper performance of which special anatomical knowledge and manipulative skill are essential.” If we are looking for it, surgical or anesthes
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