Targeting Therapies for Cancer Stem Cells
Cancer stem cells (CSCs) represent a small subpopulation of the bulk of a tumor. The CSCs possess the characteristics of self-renewal, clonal repopulation and resistance to conventional therapies, and thereby contribute to cancer metastasis and relapse. M
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ancer Stem Cells: New Horizons in Cancer Therapies
Cancer Stem Cells: New Horizons in Cancer Therapies
Surajit Pathak • Antara Banerjee Editors
Cancer Stem Cells: New Horizons in Cancer Therapies
Editors Surajit Pathak Faculty of Allied Health Sciences Chettinad Academy of Research and Education Chennai, Tamil Nadu, India
Antara Banerjee Faculty of Allied Health Sciences Chettinad Academy of Research and Education Chennai, Tamil Nadu, India
ISBN 978-981-15-5119-2 ISBN 978-981-15-5120-8 https://doi.org/10.1007/978-981-15-5120-8
(eBook)
# The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2020 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
1
Introduction to Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . Anisur Rahman Khuda-Bukhsh, Asmita Samadder, and Santu Kumar Saha
1
2
Types of Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Gautham Chengizkhan, Bharti Bisht, Sridhar Muthusami, Muralidharan Anbalagan, Ilangovan Ramachandran, and R. Ileng Kumaran
15
3
Isolation and Characterization of Cancer Stem Cells (CSCs) . . . . . Namasivayam Nalini and Bichandarkoil Jayaram Pratima
51
4
Lung and Prostate Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . Sudeep Bose, Valentina Sain, Sartaj Khurana, and Rajat Gupta
69
5
A Differential Role of miRNAs in Regulation of Breast Cancer Stem Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Shreetama Bandyopadhayaya and Chandi C. Mandal
87
6
Skin Stem Cells in Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . .
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