The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management o

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GUIDELINES

The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease Mohammed Eslam1 · Shiv K. Sarin2 · Vincent Wai‑Sun Wong3 · Jian‑Gao Fan4 · Takumi Kawaguchi5 · Sang Hoon Ahn6 · Ming‑Hua Zheng7,8 · Gamal Shiha9,10 · Yusuf Yilmaz11,12 · Rino Gani13 · Shahinul Alam14 · Yock Young Dan15 · Jia‑Horng Kao16,17,18,19 · Saeed Hamid20 · Ian Homer Cua21 · Wah‑Kheong Chan22 · Diana Payawal23 · Soek‑Siam Tan24 · Tawesak Tanwandee25 · Leon A. Adams26 · Manoj Kumar2 · Masao Omata27,28 · Jacob George1 Received: 8 July 2020 / Accepted: 6 September 2020 © Asian Pacific Association for the Study of the Liver 2020

Abstract Metabolic associated fatty liver disease (MAFLD) is the principal worldwide cause of liver disease and affects nearly a quarter of the global population. The objective of this work was to present the clinical practice guidelines of the Asian Pacific Association for the Study of the Liver (APASL) on MAFLD. The guidelines cover various aspects of MAFLD including its

Electronic supplementary material  The online version of this article (https​://doi.org/10.1007/s1207​2-020-10094​-2) contains supplementary material, which is available to authorized users. * Mohammed Eslam [email protected]

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Hepatology and Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

* Shiv K. Sarin [email protected]

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* Jacob George [email protected]

Egyptian Liver Research Institute and Hospital (ELRIAH), Sherbin, El Mansoura, Egypt

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Department of Gastroenterology, School of Medicine, Marmara University, Istanbul, Turkey

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Institute of Gastroenterology, Marmara University, Istanbul, Turkey

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Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Pangeran Diponegoro Road No. 71st, Central Jakarta 10430, Indonesia

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Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh

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Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore

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Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, National Taiwan University, 1 Chang‑Te Street, Taipei 10002, Taiwan

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Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

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Hepatitis Research Center, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan

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Department of Medical Research, National Taiwan University, National Taiwan University Hospital, Taipei, Taiwan



Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Westmead, NSW 2145, Australia

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Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India

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Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China

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Center for Fatty Liver, Depar