The BRICHOS Domain Its Proproteins and Functions
This Brief summarizes the current research on the novel BRICHOS domain, which is a chaperone domain found in a variety of proteins and is shown to exhibit anti-amyloidogenic chaperone-like functions. The BRICHOS domain is defined from sequence similaritie
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Jenny Presto Jan Johansson
The BRICHOS Domain Its Proproteins and Functions 123
SpringerBriefs in Molecular Science Protein Folding and Structure
Series editor Cláudio M. Gomes, Biosystems & Integrative Sciences Institute, Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal
About the Series Prepared by leading experts, the series contains diverse types of contributions, from snapshot volumes that allow fast entry to a general topic to those covering more specialized aspects in the field of protein folding and structure. In common, these Briefs aim at covering essential concepts, methodologies and ideas in the context of contemporary research in protein science. Through these compact volumes, this series serves as a venue for publication between typical research papers, review articles and full books, and aims at a broad audience, from students to researchers in academia and industry. About the Editor Cláudio M. Gomes joined the Gulbenkian Ph.D. p rogram in Biology and Medicine (1994) and obtained his Ph.D. (1999) and habilitation (2013) in Biochemistry from the Universidade Nova de Lisboa. He is currently Coordinating Group Leader Researcher and a c onsolidation-level fellow of the FCT Investigator Programme, at the Biosystems and Integrative Sciences Institute at the Faculty of Sciences University of Lisboa, after over a decade as group leader and assistant researcher at Universidade Nova de Lisboa (2003–2014). His research is focused on protein folding, misfolding and aggregation, mostly concerning molecular mechanisms in n eurodegenerative and metabolic diseases. He is involved in extensive publishing and editorial activities, as an author in scientific journals, member of the Editorial boards of several scientific journals and editor of thematic journals issues and books. More information about this series at http://www.springer.com/series/11958
Jenny Presto · Jan Johansson
The BRICHOS Domain Its Proproteins and Functions
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Jenny Presto Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research Karolinska Institutet Huddinge Sweden
Jan Johansson Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research Karolinska Institutet Huddinge Sweden and Department of Anatomy, Physiology and Biochemistry Swedish University of Agricultural Sciences Uppsala Sweden
ISSN 2191-5407 ISSN 2191-5415 (electronic) SpringerBriefs in Molecular Science ISSN 2199-3157 ISSN 2199-3165 (electronic) Protein Folding and Structure ISBN 978-3-319-16563-9 ISBN 978-3-319-16564-6 (eBook) DOI 10.1007/978-3-319-16564-6 Library of Congress Control Number: 2015934046 Springer Cham Heidelberg New York Dordrecht London © The Author(s) 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or informatio
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