The relationship among vitamin D, TLR4 pathway and preeclampsia
- PDF / 847,390 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 52 Downloads / 215 Views
REVIEW
The relationship among vitamin D, TLR4 pathway and preeclampsia Esther Alves de Souza1 · Luciana Pellegrini Pisani2 Received: 18 March 2020 / Accepted: 3 July 2020 © Springer Nature B.V. 2020
Abstract Preeclampsia is a pregnancy-specific syndrome that has been the greatest cause of maternal and fetal morbidity and mortality. The impaired outcomes are related to maternal and the offspring healthy in the short and long-term. Although preeclampsia origins remain unclear, it is well known that there is impaired trophoblast invasion with culminant abnormal immune response. The early and late-onset preeclampsia have been studied, the subtypes have the same difference in the placentation and inflammatory features. Dietary compounds can stimulate or inhibit the activation of immune cells. Low vitamin D intake has been linked to impaired fetal development, intrauterine growth restriction, and preeclampsia. Vitamin D has been described as an anti-inflammatory effect. It can downregulate pro-inflammatory cytokines expression by the inhibition of the Nuclear Factor-ĸB pathway signaling cascade. High vitamin D levels could attenuate the immune response. On the other hand, vitamin D deficiency may contribute to increasing pro-inflammatory state. In preeclampsia, there is a reduced expression of vitamin D receptor and its metabolism is disrupted. In this review, we aimed to discuss the role of vitamin D as an anti-inflammatory agent in relation to the pro-inflammatory process of preeclampsia through the activation of the TLR4 pathway. Although there are limited studies showing the relation between vitamin D and lower risk of preeclampsia, the maternal status of vitamin D seems to influence the risk of PE development. Therefore, vitamin D supplementation in women may be a strategy to improve pregnancy outcomes. Keywords Pregnancy · Preeclampsia · Vitamin D · Inflammation · Micronutrients Abbreviations PE Preeclampsia PAMP Pathogen-associated molecular patterns DAMP Damage-associated molecular patterns dNK Decidua Natural Killer IL Interleukine TNF- α Tumor Nuclear Factor-α IFN- γ Interferon-γ IUGR Intrauterine Growth Restriction PRR Pattern recognition receptors TLR Toll-like receptors * Luciana Pellegrini Pisani [email protected] Esther Alves de Souza [email protected] 1
Programa de Pós‑graduação em Alimentos, Nutrição e Saúde, Universidade Federal de São Paulo - UNIFESP, Santos, SP 11015021, Brazil
Departamento de Biociências, Laboratório de Nutrição e Fisiologia Endócrina, Universidade Federal de São Paulo-UNIFESP, Silva Jardim, 136, 311, 3º andar. Vila Mathias, Santos, SP 11015021, Brazil
2
LPS Lipopolysaccharide MyD88 Myeloid differentiation primary response 88 VEGF Vascular endothelial growth factor PIGF Placental growth factor sENG Soluble endoglin sFlt1 Soluble fms-like tyrosine kinase 1 VDR Vitamin D receptor RXR Retinoid X receptor VDRE Vitamin D responsive elements
Introduction Preeclampsia (PE) is a pregnancy-specific syndrome present in approximately 10% of all pr
Data Loading...
