Traditional and Modern Techniques for Radiation Treatment Planning
Before the advent of effective chemotherapy for Hodgkin lymphoma (HL) extensive radiation fields (subtotal or total nodal irradiation) were used. The techniques for delivering these very large treatment fields were developed, and they are still used occas
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Lena Specht • Joachim Yahalom (Editors)
Radiotherapy for Hodgkin Lymphoma
Prof. Lena Specht Departments of Oncology and Haematology Rigshospitalet University of Copenhagen 2100 Copenhagen Denmark
Prof. Joachim Yahalom Department of Radiation Oncology Memorial Sloan-Kettering Cancer 1275 York Ave New York 10021-6094 NY USA
ISBN: 978-3-540-78455-5 e-ISBN: 978-3-540-78944-4 DOI: 10.1007/978-3-540-78944-4 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2010930080 © Springer-Verlag Berlin Heidelberg 2011 Chapter 13 is published with kind permission of © John Wiley & Sons Ltd. 2009. All Rights Reserved. This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Cover design: eStudio Calamar, Figueres/Berlin Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
The major goal of developing this book is to optimize radiotherapy for Hodgkin lymphoma by providing clinicians who treat patients with this disease with a comprehensive account of the background for radiotherapy for Hodgkin lymphoma, the rationale for radiotherapy in a modern combined modality setting, and the data that document its contribution to the best outcome for patients. Special emphasis is given to the changes in volume and dose that have evolved over the past 2 decades, and the use of modern advanced technologies in imaging and radiotherapy planning and delivery in order to accurately target involved sites and protect adjacent organs. Radiotherapy was the first curative treatment modality for this previously lethal disease, and the achievements of the pioneers of curative radiotherapy for Hodgkin lymphoma represented some of the earliest success stories of the non-surgical treatment of cancer. With the advent of effective multiagent chemotherapy regimens, the role of radiotherapy changed. Radiotherapy now became part of multimodality treatment. Moreover, the long-term toxicity of the very extensive radiation fields of the past became apparent.
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