Transporters in Drug Development Discovery, Optimization, Clinical S
Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro charac
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Yuichi Sugiyama Bente Steffansen Editors
Transporters in Drug Development Discovery, Optimization, Clinical Study and Regulation
AAPS Advances in the Pharmaceutical Sciences Series
Series Editors Daan J.A. Crommelin Robert A. Lipper
For further volumes: http://www.springer.com/series/8825
Yuichi Sugiyama • Bente Steffansen Editors
Transporters in Drug Development Discovery, Optimization, Clinical Study and Regulation
Editors Yuichi Sugiyama Graduate School of Pharmaceutical Sciences The University of Tokyo Tokyo, Japan
Bente Steffansen Faculty of Health and Medical Sciences Department of Pharmacy Drug Transporters in ADME University of Copenhagen Copenhagen, Denmark
ISSN 2210-7371 ISSN 2210-738X (electronic) ISBN 978-1-4614-8228-4 ISBN 978-1-4614-8229-1 (eBook) DOI 10.1007/978-1-4614-8229-1 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2013947789 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
This volume of AAPS Advances in Pharmaceutical Sciences Series presents a review of the principles and progress concerning membrane transporters and how evolved understanding of membrane transporters has influenced drug development and regulatory assessment. The objective
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