Treatment of Non-infectious Uveitis
This unique, comprehensive book provides a much-needed reference on the treatment and management of non-infectious uveitis. Carefully designed, Treatment of Non-infectious Uveitis is the first book of its kind to provide an in-depth, clinically-relevant,
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Treatment of Non-infectious Uveitis
Phoebe Lin • Eric Suhler Editors
Treatment of Non-infectious Uveitis
Editors Phoebe Lin, MD, PhD Oregon Health and Science University Casey Eye Institute Portland, OR USA
Eric Suhler, MD, MPH Oregon Health and Science University OHSU-PSU School of Public Health Portland Veterans Administration Medical Center Portland, OR USA
ISBN 978-3-030-22825-5 ISBN 978-3-030-22827-9 (eBook) https://doi.org/10.1007/978-3-030-22827-9 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
The history of the therapeutic approach to inflammation, in general, and to uveitis, in particular, contains many curios. Aspirin was synthesized in 1897, and for decades, it was virtually the only known pill that reliably treated inflammation. In the 1930s, the theory that uveitis resulted from an occult infection inspired some to recommend hysterectomy or prostatectomy as treatment for uveitis [1]. Another popular approach during this era was fever therapy as could be induced by typhoid vaccine [2]. Philip Hench from the Mayo Clinic began to use adrenal derivatives to treat rheumatoid arthritis in 1948 and received the Nobel Prize for this discovery only 2 years later. Hench died of suicide, and many believe that much of his depression resulted from the realization that cortisone therapy was fraught with toxicities that he had never appreciated on the basis of the short-term studies for which he was appropriately honored. Methotrexate is now a popular immunosuppressive whose mechanism of action is partially due to poisoning leukocytes. It was developed to treat leukemia. The suggestion that methotrexate should be used to treat
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