TRP Channels in Sensory Transduction
TRP channels play a key role in sensory physiology and have been the focus of intensive investigation in recent years. This book is a comprehensive, detailed overview of the ways in which TRP channels are involved in a wide variety of sensory modalities.
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Rodolfo Madrid • Juan Bacigalupo Editors
TRP Channels in Sensory Transduction
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Editors Rodolfo Madrid Faculty of Chemistry and Biology University of Santiago de Chile Santiago, Chile
Juan Bacigalupo Faculty of Science University of Chile Santiago, Chile
ISBN 978-3-319-18704-4 ISBN 978-3-319-18705-1 (eBook) DOI 10.1007/978-3-319-18705-1 Library of Congress Control Number: 2015945247 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
In 1969, Cosens and Manning found a spontaneous mutation in Drosophila melanogaster that was revealed by a defect in the electroretinogram, in which the steady electrical response normally evoked by a sustained light pulse becomes transient. This impairment occurred in the receptor potential of the photoreceptor cells. For this reason, the mutant was termed Transient Receptor Potential, TRP. In 1989, Montell and Rubin cloned the gene and proposed that it encoded a novel ion channel, an idea that was confirmed in the following years by several laboratories. A second channel was also identified in the same cells by Phillips and coworkers in 1992, and was called TRP-like (TRPL), for its similarity with TRP. The first mammalian TRP channel sequence was reported independently in 1995 by the Montell and Birnbaumer laboratories, and it is known today as TRPC1, one of the seven members of the Canonical TRP (TRPC) channel subfamily, which also includes Drosophila TRP and TRPL. After the molecular cloning of TRPV1, the first member of the Vanilloid subfamily of TRP channels by David Julius and his group in 1997, our understanding of the molecular and cellular mechanisms underlying sensory transduction has made dramatic progress. Since then, a vast number of publications have accumulated in the lite
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