Unilateral-dominant reduction in muscle volume in female knee osteoarthritis patients: computed tomography-based analysi
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(2020) 15:543
RESEARCH ARTICLE
Open Access
Unilateral-dominant reduction in muscle volume in female knee osteoarthritis patients: computed tomography-based analysis of bilateral sides Ayumi Tsukada1, Kentaro Uchida1,2* , Jun Aikawa1, Shotaro Takano1, Dai Iwase1, Manabu Mukai1, Masayuki Miyagi1, Yuta Nanri3, Gen Inoue1 and Masashi Takaso1
Abstract Background: Muscle weakness is associated with osteoarthritis pathology. A recent study demonstrated that measuring muscle volume using computed tomography (CT)-based analysis and comparing bilateral muscles in the same patient allowed for accurate evaluation of muscle volume in unilateral hip osteoarthritis (OA) patients. Here, we evaluated muscle volume using CT-based analysis and compared bilateral muscles in knee OA (KOA) patients. Methods: CT images were obtained from 35 female radiographic KOA patients the day prior to total knee replacement surgery. Muscle volume (MV) was semi-automatically analyzed. Knee extension muscle strength (MS) was determined using a hand-held dynamometer. The severity of KOA patients’ clinical symptoms was examined using four domains of the Japanese Orthopedic Association (JOA) score. We compared the difference in MS (ΔMS) and MV (ΔMV) between the operated side (OS), which exhibited severe radiographic OA or severe pain, and the contralateral side (CS). Results: JOA score was significantly lower in the OS than CS. MV and MS were also significantly lower in the OS than CS. There was no correlation between MV and MS or between MV and MS as a percentage of body weight on either side. However, ΔMV was positively correlated with ΔMS and pain on walking in the JOA. Conclusions: We evaluated MV and MS using bilateral CT images of the legs of KOA patients. A reduction in MV was observed on the OS, and was correlated with a reduction in MS and pain on walking. Bilateral CT image analysis may be useful for evaluating the relationship between OA pathology and muscle atrophy. Keywords: Computed tomography, Bilateral, Muscle volume, Muscle strength, Osteoarthritis
Background Knee osteoarthritis (KOA) is a well-known musculoskeletal disorder and a key cause of disability, particularly in elderly individuals [1]. A number of biomechanical pathways likely play major roles in KOA. For example, excessive * Correspondence: [email protected] 1 Department of Orthopedic Surgery, Kitasato University School of Medicine, 1-15-1 Minami-ku Kitasato, Sagamihara City, Kanagawa 252-0374, Japan 2 Shonan University of Medical Sciences Research Institute, Nishikubo 500, Chigasaki City, Kanagawa 253-0083, Japan Full list of author information is available at the end of the article
mechanical stress arising from either a reduction in loadbearing area on the surface of a joint or applying a heavy load can halt the repair of damaged joint tissue [2]. Muscle weakness is a key measure of the extent of disability in OA patients [3]. A number of reports have demonstrated that a reduction in lean mass in the lower limbs is common in OA patients [4], and this reduct
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