Vitamin D Physiology, Molecular Biology, and Clinical Applications
In Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Second Edition, leading researchers provide a comprehensive, highly readable overview of the biological functions and clinical applications of vitamin D and its metabolites. Topics ra
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H E A L T H
Vitamin D
Physiology, Molecular Biology, and Clinical Applications Second Edition
Edited by
Michael F. Holick
Nutrition and Health Adrianne Bendich, PhD, FACN, Series Editor
For other titles published in this series, go to www.springer.com/series/7659
Vitamin D Physiology, Molecular Biology, and Clinical Applications Second Edition Edited by
Michael F. Holick, Ph.D., M.D. Boston University School of Medicine, Professor of Medicine, Physiology and Biophysics, Director, Vitamin D, Skin and Bone Research Laboratory, Boston Medical Center, Program Director, General Clinical Research Unit, Boston, MA
Editor Michael F. Holick, Ph.D., M.D. 85 East Newton St. Boston MA 02118 M-1013 USA [email protected]
Series Editor Adrianne Bendich, PhD GlaxoSmithKline Consumer Healthcare Parsippany, NJ [email protected]
ISBN 978-1-60327-300-8 e-ISBN 978-1-60327-303-9 DOI 10.1007/978-1-60327-303-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010922338 © Springer Science+Business Media, LLC 2004, 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Dedication
I dedicate this book to my best friend, colleague, and business partner for more than 37 years, my loving wife Sally who has always been supportive of my career and has been the absolute joy and love of my life.
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In Memoriam
Louis V. Avioli M.D. Last year I participated in an International Bone and Mineral Society conference for trainees and junior faculty focusing on successful career planning. My message was simple; pick the right mentor. It’s a strategy I know well because any success I’ve enjoyed in my career reflects the wisdom and unselfishness of my mentor, Lou Avioli. Lou was a self-described public school kid from New Jersey who earned a full scholarship to Princeton from which he graduated magna cum laude. He received his M.D. from Yale and became interested in ca
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