Relationship of Neuron Specific Enolase and Protein S-100 Concentrations in Systemic and Jugular Venous Serum to Injury
Neuron specific enolase (NSE) and protein S-100 have previously been described as markers of brain injury. We aimed to discover whether concentrations of either were raised in arterial and jugular venous serum after traumatic brain injury, and whether ser
- PDF / 653,238 Bytes
- 3 Pages / 595.279 x 793.683 pts Page_size
- 12 Downloads / 168 Views
Relationship of Neuron Specific Enolase and Protein S-100 Concentrations in Systemic and Jugular Venous Serum to Injury Severity and Outcome after Traumatic Brain Injury E. G. McKeating, P. J. D. Andrews, and L. Mascia Department of Anaesthetics, University of Edinburgh, Western General Hospital, Edinburgh, U.K.
Summary Neuron specific enolase (NSE) and protein SolDO have previously been described as markers of brain injury. We aimed to discover whether concentrations of either were raised in arterial and jugular venous serum after traumatic brain injury, and whether serum profiles were related to injury severity and neurological outcome. We recruited 22 patients with a traumatic brain injury who were admitted to the intensive care unit. Paired arterial and jugular venous blood samples were taken on admission, and at 24, 48 and 96hrs after injury. Samples were analysed for NSE and SolDO by RIA. Concentrations of both NSE and S-l 00 were increased above controls - mean NSE concentration was highest on admission, whilst mean S-lOO peaked at 24 hours after injury. There was a small, but significant difference between jugular venous and arterial concentrations of S-lOO (p = 0.022). High NSE and S-IOO concentrations were significantly related to poor neurological outcome (p = 0.004 and p < 0.001 respectively). Both serum NSE and S-lOO may be of some value in helping to predict outcome after a traumatic brain injury. Keywords: Astroglial specific protein; neuron specific enolase; protein S-lOO; traumatic brain injury.
Introduction Prediction of outcome after traumatic brain injury (TEl) is difficult. There has recently been interest in the measurement of neuron specific enolase (NSE), an isoform of the glycolytic enzyme enolase, which is found in neurons and neuroendocrine cells, in the serum and cerebrospinal fluid (CSF) after brain injury [1,3]. Some investigators have claimed that it is a good quantitative marker of neuronal damage. Others have suggested that measurement of serum or CSF concentrations of protein S-100, a protein present predominantly in astroglial cells, is a suitable quantitative marker of severity of brain injury [4].
Our aim was to measure the profiles of NSE and S100 in both arterial and jugular venous serum after TBI. We hypothesised that serum concentrations would be raised, that jugular venous concentrations would be higher than arterial and that the serum profiles would be related to injury severity and neurological outcome.
Materials and Methods We investigated the difference between jugular venous (1V) and arterial concentrations of NSE and S-100 in 21 patients with TBI admitted to the intensive care unit. Data of patient characteristics, consisting of sex, age, Injury Severity Score (ISS) and Glasgow Coma Score (GCS) after non-surgical resuscitation were collected on admission (Table 1). If a patient had an Abbreviated Injury Score>1 for a body region other than the head/neck, he/she was classified as having extracranial injuries. If this was not the case then the patient's injury was cl
Data Loading...
