Lymphocyte Signal Transduction

Signal transduction through leukocyte receptors involves a variety of signaling molecules including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors, membrane phospholipids as well as others. These signal transducers, regulated

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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science DAVID KRITCHEVSKY, Wistar Institute ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research RODOLFO PAOLETTI, University of Milan

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LYMPHOCYTE SIGNAL TRANSDUCTION Edited by

Constantine Tsoukas San Diego State University San Diego, California

Editor: Constantine Tsoukas San Diego State University San Diego, CA 92182 USA [email protected]

Library of Congress Control Number: 2006922768 Printed on acid-free paper. ISBN 10: 0-387-31335-4 ISBN-13: 978-0387-31335-1

Proceedings of the 3rd Lymphocyte Signal Transduction Conference, held May 27-June 1, 2005, in Crete, Greece. © 2006 Springer Science+Business Media, LLC All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed in the United States of America. 9 8 7 6 5 4 3 2 1 springer.com

Foreword

Signal transduction through leukocyte receptors involves a variety of signaling molecules — including kinases, phosphatases, adaptor proteins, small GTPases GTP exchange factors,