Risperidone
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Acute eosinophilic pneumonia: case report A 51-year-old man developed acute eosinophilic pneumonia during treatment with risperidone for schizophrenia [route, dosage and duration of treatment to reactions onset not stated]. The man, who had schizophrenia, started receiving treatment with risperidone. Subsequently, he was admitted with gradual worsening of shortness of breath. A possible diagnosis of asthma or obstructive lung disease exacerbation was made, and he was discharged on unspecified bronchodilators and steroids. However, he was readmitted due to persistent shortness of breath, which had worsened further. On readmission, he had leucocytosis with 34% eosinophils. His oxygen saturation ranged between 60% and 70%, and he was very hypoxic. His arterial blood gas showed a pH of 7.38, and partial pressure of oxygen was 56mm Hg. Consequently, hypoxic respiratory failure was detected, and he was intubated. His chest CT revealed multifocal pneumonia. In the ICU, he underwent various laboratory tests, which appeared negative. Then, a bronchoscopy was performed and bronchoalveolar lavage was sent for evaluation, which revealed 77% of eosinophilia, consistent with eosinophilic pneumonia. Bronchial wash culture and sputum culture grew normal flora. The man’s therapy with risperidone discontinued. He was treated with unspeciifed bronchodilation and corticosteroids with improvement, by the time he was weaned off from mechanical ventilation. He was then discharged on prescription of mirtazapine, benztropine and olanzapine for schizophrenia. Parthvi R, et al. Risperidone-Associated Acute Eosinophilic Pneumonia. American Journal of Therapeutics 27: e554-e556, No. 5, Sep-Oct 2020. Available from: URL: http:// 803505469 doi.org/10.1097/MJT.0000000000000800
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Reactions 10 Oct 2020 No. 1825
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