Risperidone
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Risperidone Periorbital oedema: case report A 39-year-old woman with paranoid schizophrenia developed periorbital oedema during treatment with longacting risperidone. The woman had a 5-year history of paranoid schizophrenia and poor compliance with medication. Delusions and auditory hallucinations prompted her admission 1 month after she became noncompliant. In the past 7 months she had tolerated treatment with oral risperidone 4mg. On admission, oral risperidone 4mg at bedtime was readministered and she received an intramuscular injection of long-acting risperidone 50mg on hospital day 3 due to poor compliance as an outpatient. Her psychotic symptoms and agitation gradually improved; however, she developed marked periorbital oedema on day 14, with swollen eyelids that partially closed her eyes. All laboratory test results were unremarkable. Although oral risperidone was stopped, the periorbital oedema persisted until 4 weeks after the risperidone injection. Following complete resolution of the oedema, the woman was treated with olanzapine. Author comment: "Because [the patient] already had taken oral risperidone for 7 months without showing any relevant adverse reactions, risperidone long-acting injection was thought to be the culprit of her periorbital edema." Pelizza L. Long-acting risperidone-induced periorbital edema. Journal of Clinical 801118762 Psychopharmacology 28: 709-710, No. 6, Dec 2008 - Italy
0114-9954/10/1231-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 6 Dec 2008 No. 1231
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