RNAi and microRNA-Mediated Gene Regulation in Stem Cells Methods, Pr
Recent stem cell research has revealed that miRNA and RNAi-mediated gene regulation is one of the vital determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluri
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MO L E C U L A R BI O L O G Y
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For other titles published in this series, go to www.springer.com/series/7651
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RNAi and MicroRNA-Mediated Gene Regulation in Stem Cells Methods, Protocols, and Applications
Edited by
Baohong Zhang and Edmund J. Stellwag Department of Biology, East Carolina University, Greenville, NC, USA
Editors Baohong Zhang Department of Biology East Carolina University 27858-4353 Greenville North Carolina Howell Science Complex USA [email protected]
Edmund J. Stellwag Department of Biology East Carolina University 27858-4353 Greenville North Carolina Howell Science Complex USA [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-60761-768-6 e-ISBN 978-1-60761-769-3 DOI 10.1007/978-1-60761-769-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010928837 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Cover illustration: Lentiviral transduction efficiency in hMSCs Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface At present, research in the areas of stem-cell biology, RNA interference (RNAi), and microRNAs (miRNAs) is the source of immense scientific and medical interest. Despite their apparent differences, stem-cell biology, RNAi, and miRNA are increasingly being shown to have a great deal in common. Small RNAs, particularly those represented by miRNAs and RNAi, play a central role in the regulation of embryonic and adult stem-cell development. Recent research has revealed that in stem cells, miRNA- and RNAi-mediated gene regulation is one of the determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluripotent cell-fate determination. From a technological perspective, RNAi and miRNA-based methods are being developed both to study the processes of stem-cell differentiation and create clinically useful therapies for the treatment of disease and preservation of wellness. The promise is that harnessing the stem-cell regulatory activities of RNAi and miRNA will lead to rapid advancement in the use of these small RNA molecules as therapeutic agents in ar
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