Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping
- PDF / 1,090,082 Bytes
- 38 Pages / 595.276 x 790.866 pts Page_size
- 74 Downloads / 220 Views
REVIEW
Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping Germain Honvo
. Laetitia Lengele´ . Alexia Charles .
Jean-Yves Reginster . Olivier Bruye`re
Received: August 18, 2020 / Accepted: September 23, 2020 The Author(s) 2020
ABSTRACT Introduction: There is currently no diseasemodifying drug for osteoarthritis (OA), and some safety concerns have been identified about the leading traditional drugs. Therefore, research efforts have focused on alternatives such as supplementation with collagen derivatives. The objective of this scoping review is to examine the extent, range, and nature of research, and to summarize and disseminate research findings on the effects of collagen Digital Features To view digital features for this article go to https://doi.org/10.6084/m9.figshare.12987830. Electronic Supplementary Material The online version of this article (https://doi.org/10.1007/s40744020-00240-5) contains supplementary material, which is available to authorized users. G. Honvo (&) L. Lengele´ A. Charles J.-Y. Reginster O. Bruye`re Division of Public Health, Epidemiology and Health Economics, University of Lie`ge, Lie`ge, Belgium e-mail: [email protected] G. Honvo L. Lengele´ A. Charles J.-Y. Reginster O. Bruye`re World Health Organization (WHO) Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, University of Lie`ge, Lie`ge, Belgium J.-Y. Reginster Chair for Biomarkers Research, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
derivatives in OA and cartilage repair. The purpose is to identify gaps in the current body of evidence in order to further help progress research in this setting. Methods: The databases Medline, Scopus, CENTRAL, TOXLINE, and CDSR were comprehensively searched from inception to search date. After studies selection against eligibility criteria, following recommended methods, data were charted from the retrieved articles and these were subsequently synthesized. Numerical and graphical descriptive statistical methods were used to show trends in publications and geographical distribution of studies. Results: The systematic literature search identified a total of 10,834 records. Forty-one published studies were ultimately included in the review, 16 of which were preclinical studies and 25 were clinical studies (including four systematic reviews/meta-analyses). Collagen hydrolysate (CH) and undenatured collagen (UC) were the two types of collagen derivatives studied, with a total of 28 individual studies on CH and nine on UC. More than a third of studies originated from Asia, and most of them have been published after 2008. Oral forms of collagen derivatives were mainly studied; three in vivo preclinical studies and three clinical trials investigated intra-articularly injected CH. In most of the clinical trials, treatment durations varied between 3 and 6 months, with the shortest being 1.4 months and the longest 11 months. All
Data Loading...
