Role of hydrolytic degradation of polylactide drug carriers in developing micro- and nanoscale polylactide-based drug do
- PDF / 846,311 Bytes
- 12 Pages / 612 x 792 pts (letter) Page_size
- 67 Downloads / 152 Views
Russian Chemical Bulletin, International Edition, Vol. 69, No. 8, pp. 1416—1427, August, 2020
Role of hydrolytic degradation of polylactide drug carriers in developing micro- and nanoscale polylactide-based drug dosage forms* Yu. V. Ermolenko,a,b A. S. Semyonkin,а,b,c Yu. V. Ulianova,а T. S. Kovshova,а,d О. О. Maksimenko,a,b and S. E. Gelperinaа,b aD.
I. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya pl., 125047 Moscow, Russian Federation. Fax: +7 (499) 978 8733. E-mail: [email protected] bDrugs Technology LLC, 2a Rabochaya ul., Build. 31, Khimki, 141400 Moscow Region, Russian Federation. cI. M. Sechenov First Moscow State Medical University, 8 ul. Trubetskaya, build. 2, 119991 Moscow, Russian Federation. dM. V. Lomonosov Moscow State University, 1 Leninskie Gory, 119991 Moscow, Russian Federation The present analytical survey explores different aspects of hydrolytic degradation of drug dosage forms (DF) based on polylactides, homopolymers of lactic acid (PLA) and copolymers of lactic and glycolic acids (PLGA). The study includes various scientific data from multiple sources describing the effect of the PLGA nanocarrier hydrolytic degradation rate on the profile of drug release from the DFs intended for intravenous and intramuscular administration, including micro- and nanoparticles, and implants. The following aspects are explored in the review: design of experiments aimed at studying the hydrolytic degradation kinetics of PLGA carriers; commonly employed analytical methods; interpretation of the mechanism of PLGA-based DF hydrolytic degradation; factors that influence the hydrolytic degradation rate of PLGA drug carriers as part of DFs; interrelation between the processes of polymer carrier hydrolytic degradation and drug substance release from the PLGA-based DFs. Key words: polylactides, copolymers of lactic and glycolic acids, nanoparticles, microspheres, hydrolytic degradation of polylactides, drug release.
Introduction Polylactides, homopolymers of lactic acid (PLA) or its copolymers with polyglycolic acid (PLGA), are widely used in medicine. PLGA with a different unit ratio of lactic and glycolic acids are used in practice. In this review, the term "polylactide" is applied to the entire group of these polymers.
PLGA x is the number of monomeric units of lactic acid, y is the number of monomeric units of glycolic acid (у = 0, PLA).
* Based on the materials of the XXI Mendeleev Congress on General and Applied Chemistry (September 9—13, 2019, St. Petersburg, Russia).
Polylactides are used in pharmaceuticals for the manufacture of drug dosage forms (DFs) and for the production of various medical products. For example, surgical products and consumables are made from PLA, and they are also used in tissue engineering. The components of an artificial extracellular matrix are developed on a basis of polylactides. Dental and surgical implants, cardiological stents, dermal fillers and much more are manufactured from polylactides.1—3 Such widespread use is, among other reasons, due to the ability of pol
Data Loading...
