Short Pulse Laser Systems for Biomedical Applications

This book presents practical information on the clinical applications of short pulse laser systems and the techniques for optimizing these applications in a manner that will be relevant to a broad audience, including engineering and medical students as we

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Kunal Mitra Stephanie Miller

Short Pulse Laser Systems for Biomedical Applications

123

SpringerBriefs in Applied Sciences and Technology

More information about this series at http://www.springer.com/series/8884

Kunal Mitra • Stephanie Miller

Short Pulse Laser Systems for Biomedical Applications

Kunal Mitra Department of Biomedical Engineering Florida Institute of Technology Melbourne, FL, USA

Stephanie Miller Department of Mechanical & Aerospace Engineering Florida Institute of Technology Melbourne, FL, USA

ISSN 2191-530X     ISSN 2191-5318 (electronic) SpringerBriefs in Applied Sciences and Technology ISBN 978-3-319-54252-2    ISBN 978-3-319-54253-9 (eBook) DOI 10.1007/978-3-319-54253-9 Library of Congress Control Number: 2017932907 © The Author(s) 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

Short pulse laser systems are useful for both subsurface tissue imaging, and ­laser-­induced thermal therapy (LITT), which hold great promise in cancer diagnostics and treatment. Such laser systems may be used alone, or in combination with optically active nanoparticles specifically administered to the tissues of interest for enhanced contrast in imaging and precise heating during LITT. Mathematical and computational models of short pulse laser-tissue interactions that consider the transient radiative transport equation coupled with a bio-heat equation considering the initial transients of laser heating were developed to analyze the laser-tissue interaction during imaging and therapy. Experiments were first performed to characterize the tissue optical properties needed to optimize the dose for thermal therapy. Experiments w

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