Signal Transduction Protocols
It is increasingly clear that signal transduction is a highly organized and integrated process. Divided into two convenient sections, Signal Transduction Protocols, Third Edition focuses on experimental approaches to better understand the complexity
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
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Signal Transduction Protocols Edited by
Louis M. Luttrell Departments of Medicine and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA; Charleston VA Medical Center, Charleston, SC, USA
Stephen S.G. Ferguson The J. Allyn Taylor Centre for Cell Biology, Robarts Research Institute, The University of Western Ontario, London, ON, Canada; Department of Physiology & Pharmacology, The University of Western Ontario, London, ON, Canada
Editors Louis M. Luttrell MD, PhD Departments of Medicine and Biochemistry & Molecular Biology Medical University of South Carolina Charleston, SC, USA Charleston VA Medical Center, Charleston SC, USA [email protected]
Stephen S. G. Ferguson PhD The J. Allyn Taylor Centre for Cell Biology Robarts Research Institute The University of Western Ontario London, ON, Canada Department of Physiology & Pharmacology The University of Western Ontario London, ON, Canada [email protected]
ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-159-8 e-ISBN 978-1-61779-160-4 DOI 10.1007/978-1-61779-160-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011935994 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Signal transduction is the process whereby a physical or chemical stimulus in the extra cellular environment is detected by a receptor on the plasma membrane or in the cytosol or nucleus of a sensitive cell and translated into a chemical or electrochemical signal that produces a change in cellular metabolism. Rather than representing a series of simple linear cascades, it is increasingly clear that signal transduction is a highly organized and integrated process. Extensive crosstalk between signaling cascades, communicated directly through receptor oligomerization or indirectly through the activation of autocrine and paracrine feedback loops, enables one type of receptor to modulate activity in multiple intracellular pathways. Additional factors impose spatial or
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