Introduction to Cellular Signal Transduction
Our understanding of biological communication has grown significantly during the past decade. The advances in knowledge about the chemical nature of signals and their corresponding reception by specialized cells have led to identification, characterizatio
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Series Editor V. K. Moudgil
BOOKS IN THE SERIES Introduction to Cellular Signal Transduction Ari Sitaramayya, Editor ISBN 0-8176-3982-9 Estrogens, Progestins and their Antagonists: Volume I, Health Issues Edward J. Pavlik, Editor ISBN 0-8176-3947-0 Estrogens, Progestins and their Antagonists: Volume II, Functions and Mechanisms of Action Edward J. Pavlik, Editor ISBN 0-8176-3854-7 Hormones and Cancer w. V. Vedeckis, Editor ISBN 0-8176-3797-4 Steroid Hormone Receptors: Basic and Clinical Aspects V. K. Moudgil, Editor ISBN 0-8176-3694-3
Introduction to Cellular Signal Transduction
Ari Sitaramayya EDITOR
Springer Science+Business Media, LLC
Ari Sitaramayya Eye Research Institute Oakland University 422 Dodge Hall Rochester, MI 48309-4480 USA
Library of Congress Cataloging-in-Publication Data Sitaramayya, Ari. Introduction to cellular signal transduction I Ari Sitaramayya. p. cm. - (Hormones in health and disease) Inc1udes bibliographical references and index. ISBN 978-1-4612-7370-7 ISBN 978-1-4612-1990-3 (eBook) DOI 10.1007/978-1-4612-1990-3 1. Cellular signal transduction. 2. Second messengers (Biochemistry) 3. G proteins. 1. Title. II. Series. QP517.C45S58 1999 98-25749 572' .69-dc21 CIP Printed on acid-free paper. © 1999 Springer Science+Business Media New York Originally published by Birkhăuser Boston in 1997 Softcover reprint of the hardcover 1st edition AH rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use of general descriptive names, trade names, trademarks, etc. in this publication even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may according1y be used freely byanyone.
ISBN978-1-4612-7370-7
SPIN 10842357
Typeset by Northeastem Graphic Services, Inc., Hackensack, NJ.
9876543 2
For Usha, Vani, and Aruna
Contents
FOREWORD . . . . . . . . . . . CONTRIBUTORS . . .
Part I: Overview
. . ix
. xi 1
Ari Sitaramayya
Part ll: Receptors and G-proteins
5
1. Cell Surface Receptors: Mechanisms of Signaling and Inactivation . . . . . . . . . . . . . . . . . .. .. . . . . 7 Ari Sitaramayya and Nigel W. Bunnett
2. Heterotrimeric G-proteins: Structure, Regulation, and Signaling Mechanisms . . . . . . . . . . . . . . . . . . . . . . . . 29 Theodore Wensel
3. Ras- and Rho-Related Small Molecular Weight G-proteins: Structure and Signaling Mechanisms .. . . . .. 47 Uma Prabhakar and Panna I Nambi
Part m: Second Messengers
65
4. Cyclic Nucleotides: Synthesis by Adenylyl and Guanylyl Cyclases . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 Akio Yamazaki
5. Phospholipases: Generation of Lipid-Derived
