Signaling at the Cell Surface in the Circulatory and Ventilatory Systems
The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory sys
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Marc Thiriet
Signaling at the Cell Surface in the Circulatory and Ventilatory Systems
Marc Thiriet Project-team INRIA-UPMC-CNRS REO Laboratoire Jacques-Louis Lions, CNRS UMR 7598 Université Pierre et Marie Curie Place Jussieu 4 75252 Paris Cedex 05 France
ISSN 2193-1682 ISBN 978-1-4614-1990-7 e-ISBN 978-1-4614-1991-4 DOI 10.1007/978-1-4614-1991-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011943886
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Contents
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Signal Transduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1 Main Signaling Features . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.1 Types of Cell Communications . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.2 Phases of Cell Communications . . . . . . . . . . . . . . . . . . . . . . . . 1.1.3 Main Signaling Mediators . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.4 Signaling Cascade . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.5 Features of Signaling Cascades . . . . . . . . . . . . . . . . . . . . . . . . . 1.2 Signal Processing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.1 Transducers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.2 Molecule Translocation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.3 Proteic Interactions – Interactomes . . . . . . . . . . . . . . . . . . . . . 1.2.4 Lipidic Interactions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.5 Protein Modifications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.6 Reversible Oxidation of Kinases and Phosphatases . . . . . . . . 1.2.7 Receptor Endocytosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.8 Gene Expression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.3 Signaling Triggered by Ligand-Bound Receptor . . . . . . . . . . . . . .
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